Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs.

Abstract

The stimulation of fibroblast growth factor receptors (FGFRs) with distinct FGF ligands generates specific cellular responses. However, the mechanisms underlying this paradigm have remained elusive. Here, we show that FGF-7 stimulation leads to FGFR2b degradation and, ultimately, cell proliferation, whereas FGF-10 promotes receptor recycling and cell… (More)
DOI: 10.1016/j.molcel.2013.08.002

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