Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile.

@article{Dingle2008FunctionalPO,
  title={Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile.},
  author={T. Dingle and Stefanie Wee and G. Mulvey and A. Greco and E. Kitova and Jiangxiao Sun and S. Lin and J. S. Klassen and M. Palcic and K. Ng and G. Armstrong},
  journal={Glycobiology},
  year={2008},
  volume={18 9},
  pages={
          698-706
        }
}
The biological and ligand-binding properties of recombinant C-terminal cell-binding domains (CBDs) and subdomains of the two large exotoxins, Toxin A (TcdA) and Toxin B (TcdB) expressed by Clostridium difficile were examined in the hemagglutination and Verocytotoxicity neutralization assays and by qualitative affinity chromatography using Sepharose-linked alpha Gal(1,3)betaGal(1,4)beta Glc as well as the direct electrospray ionization mass spectrometry (ES-MS) assay. These studies revealed that… Expand
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