Functional properties of sodium channels do not depend on the cytoskeleton integrity.

@article{Morn2000FunctionalPO,
  title={Functional properties of sodium channels do not depend on the cytoskeleton integrity.},
  author={Oscar Mor{\'a}n and Paolo Tammaro and Mario Nizzari and Franco Conti},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={276 1},
  pages={204-9}
}
Several observations suggest an interaction of the sodium channel alpha-subunit with the cytoskeletal structures. However, there is a wide variability in the results of experiments of heterologous expression in Xenopus oocytes and studies on mammalian cells are sometimes contradictory. In general, there has been no direct demonstration that ad hoc large perturbations of the cytoskeleton modify the intrinsic properties of the sodium channels expressed endogenously or heterologously in plasma… CONTINUE READING

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