Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.

@article{Han2003FunctionalPO,
  title={Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.},
  author={Jaehee Han and Dawon Kang and Donghee Kim},
  journal={American journal of physiology. Cell physiology},
  year={2003},
  volume={285 3},
  pages={C529-38}
}
TALK-1a, originally isolated from human pancreas, is a member of the tandem-pore K+ channel family. We identified and characterized three novel splice variants of TALK-1 from human pancreas. The cDNAs of TALK-1b, TALK-1c, and TALK-1d encode putative proteins of 294, 322, and 262 amino acids, respectively. TALK-1a and TALK-1b possessed all four transmembrane segments, whereas TALK-1c and TALK-1d lacked the fourth transmembrane domain because of deletion of exon 5. Northern blot analysis showed… CONTINUE READING

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