Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts.

@article{Srensen2005FunctionalPA,
  title={Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts.},
  author={Andreas Toft S\orensen and Lachlan Thompson and Deniz Kirik and Anders Bj{\"o}rklund and Olle Lindvall and Merab Kokaia},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 10},
  pages={2793-9}
}
Intrastriatal grafts of fetal ventral mesencephalic tissue, rich in dopaminergic neurons, can reverse symptoms in Parkinson's disease. For development of effective cell replacement therapy, other sources of dopaminergic neurons, e.g. derived from stem cells, are needed. However, the electrophysiological properties grafted cells need to have in order to induce substantial functional recovery are poorly defined. It has not been possible to prospectively identify and record from dopaminergic… CONTINUE READING

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