Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene

  title={Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene},
  author={A. Heils and A. Teufel and S. Petri and M. Seemann and D. Bengel and U. Balling and P. Riederer and K. Lesch},
  journal={Journal of Neural Transmission / General Section JNT},
  • A. Heils, A. Teufel, +5 authors K. Lesch
  • Published 2005
  • Biology, Medicine
  • Journal of Neural Transmission / General Section JNT
  • We have isolated and characterized the 5′-flanking region and the proximal polyadenylation site of the human 5-HT transporter gene. The major gene transcript is 2,793 bp in length and it contains 208 bp of 5′-untranslated region (5′-UTR) and 694 bases of 3′-UTR. While only a single mRNA species occurs in rats and mice, the most proximal signal for polyadenylation in the human gene appears to be highly degenerate in comparison to the rat and murine motif. This polyadenylation signal-like motif… CONTINUE READING
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