Functional profile of tissue-infiltrating and circulating CD68+ cells in giant cell arteritis. Evidence for two components of the disease.

@article{Wagner1994FunctionalPO,
  title={Functional profile of tissue-infiltrating and circulating CD68+ cells in giant cell arteritis. Evidence for two components of the disease.},
  author={Anna Dorothea Wagner and J{\"o}rg J Goronzy and Cornelia M Weyand},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 3},
  pages={
          1134-40
        }
}
Macrophages represent a critical component in the inflammatory lesions of giant cell arteritis. By combining immunohistochemistry and in situ hybridization, we have analyzed the functional heterogeneity of tissue-infiltrating macrophages in patients with untreated vasculitis. 20% of macrophages in temporal artery tissue synthesized IL-6-specific mRNA and produced IL-6 and IL-1 beta proteins. IL-6 and IL-1 beta production was not limited to CD68+ cells in the lymphoid aggregates but was a… CONTINUE READING
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