Functional profile of the isolated uremic nephron. Evidence of proximal tubular "memory" in experimental renal disease.

@article{Trizna1981FunctionalPO,
  title={Functional profile of the isolated uremic nephron. Evidence of proximal tubular "memory" in experimental renal disease.},
  author={Walter Trizna and Norimoto Yanagawa and Yaacov Bar-Khayim and Brittany Houston and Leon G. Fine},
  journal={The Journal of clinical investigation},
  year={1981},
  volume={68 3},
  pages={
          760-7
        }
}
In experimental models of glomerular and nonglomerular renal disease, single nephron filtration rate and proximal tubular reabsorption of fluid decrease or increase in parallel in the same nephron. To assess whether intrinsic adaptations in proximal tubular function, i.e., changes that are independent of the peritubular or humoral milieu, contribute to this phenomenon, segments of rabbit late superficial proximal convoluted tubules (PCT) were studied by in vitro perfusion. PCT were obtained… CONTINUE READING
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