Functional processing of fertilin: evidence for a critical role of proteolysis in sperm maturation and activation.

  title={Functional processing of fertilin: evidence for a critical role of proteolysis in sperm maturation and activation.},
  author={Carl P. Blobel},
  journal={Reviews of reproduction},
  volume={5 2},
  • C. Blobel
  • Published 1 May 2000
  • Biology
  • Reviews of reproduction
Fertilin is a sperm surface protein with an essential role in fertilization. It is required for the migration of spermatozoa through the oviduct, for binding to the zona pellucida, and for efficient binding to the egg plasma membrane. Fertilin consists of two subunits, fertilin alpha and beta, both of which belong to the metalloprotease-disintegrin protein family (ADAMs). Fertilin alpha and beta are made as larger precursors that are processed proteolytically at different stages of sperm… 

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