Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus.

@article{RoszkowskaGancarz2014FunctionalPO,
  title={Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus.},
  author={Małgorzata Roszkowska-Gancarz and Alina Kurylowicz and Jacek Polosak and Małgorzata Mossakowska and Edward Franek and M Puzianowska-Kuźnicka},
  journal={Endokrynologia Polska},
  year={2014},
  volume={65 1},
  pages={11-6}
}
INTRODUCTION Longevity is commonly associated with good health and with delayed onset of age-related diseases with usually benign course. Leptin (LEP) significantly affects metabolism and numerous functions of the organism. To find out if extreme longevity and its phenotype are associated with genetic variants of leptin and leptin receptor (LEPR) genes, we analysed the frequencies of the -2548 G/A and +19 G/A LEP, as well as the K109R, Q223R, and K656N LEPR polymorphisms in centenarians and in… CONTINUE READING

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