Functional polymorphisms of DEFB1 gene in type 1 diabetes Brazilian children.

@article{Guimares2009FunctionalPO,
  title={Functional polymorphisms of DEFB1 gene in type 1 diabetes Brazilian children.},
  author={Rafael Lima Guimar{\~a}es and Ludovica Segat and C{\'i}ntia Renata Costa Rocha and Lucas Andr{\'e} Cavalcanti Brand{\~a}o and Valentina Zanin and Jacqueline C. Araujo and Michel Satya Naslavsky and Jos{\'e} Luiz de Lima Filho and Sergio Crovella},
  journal={Autoimmunity},
  year={2009},
  volume={42 5},
  pages={406-13}
}
We analyzed three functional 5' un-translated region beta-defensin 1 (DEFB1) single nucleotide polymorphism (SNPs) in a group of 170 type 1 diabetes (T1D) patients. In order to evaluate the SNPs influence on the disease onset and the development of other autoimmune disorder, such as celiac disease (CD) and autoimmune thyroid disease (AITD), patients were stratified according to the presence of AITD, CD, and both AITD and CD. As control group, we studied 191 healthy children and adolescent not… CONTINUE READING