Functional polymorphisms in the CD44 gene and acute myeloid leukemia cancer risk in a Chinese population.

@article{Wu2015FunctionalPI,
  title={Functional polymorphisms in the CD44 gene and acute myeloid leukemia cancer risk in a Chinese population.},
  author={Hongchun Wu and Jieqiong Deng and Jian Zheng and Yonghe You and Na Li and Wei Li and Depei Wu and Yifeng Zhou},
  journal={Molecular carcinogenesis},
  year={2015},
  volume={54 2},
  pages={102-10}
}
CD44 is such one adhesion molecule that mediates interactions between acute myeloid leukemia (AML) cells and stromal. It has been demonstrated that CD4 plays a critical role in AML development. However, studies of functional single nucleotide polymorphisms (SNPs) in CD44 gene have not touched upon AML. This case-control study probed the contribution of functional SNPs in CD44 gene to AML susceptibility in eastern Chinese population. Five representative SNPs of CD44 (rs10836347C>T, rs13347C>T… CONTINUE READING

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