Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults.

@article{Levine2012FunctionalPI,
  title={Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults.},
  author={Andrew J. Levine and Janet S. Sinsheimer and Robert M. Bilder and Paul Shapshak and Elyse J. Singer},
  journal={Journal of clinical and experimental neuropsychology},
  year={2012},
  volume={34 1},
  pages={78-91}
}
UNLABELLED Dopaminergic dysfunction is a putative mechanism underlying HIV-associated neurocognitive disorders. Dopamine transporter (DAT), brain-derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) have been specifically implicated. We report analyses examining the main effects of functional polymorphisms within dopamine-modulating genes, as well as their interactive effects with disease severity, upon neurocognitive functioning in HIV+ adults. METHOD A total of 184… CONTINUE READING
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