Functional polymorphisms in Nrf2: implications for human disease.

  title={Functional polymorphisms in Nrf2: implications for human disease.},
  author={H Cho and Jacqui M Marzec and Steven R. Kleeberger},
  journal={Free radical biology & medicine},
  volume={88 Pt B},
Nuclear factor (erythroid derived)-2 like 2 (NFE2L2), also known as nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2), is a ubiquitous transcription factor essential for protecting cells and tissues from oxidative stress-induced injury. Positional cloning and studies with Nrf2 knockout mice have identified important roles for this transcription factor in disease phenotypes for many organ systems. Studies have also characterized the means through which human Nrf2 is regulated and the… CONTINUE READING
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