Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia.

@article{Nagai1998FunctionalPO,
  title={Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia.},
  author={Miho Nagai and Kunihiko Tani and Yurie Nakamura and Atsuchi Ino and Kyoko Ohara},
  journal={Psychiatry research},
  year={1998},
  volume={81 2},
  pages={117-23}
}
Several studies showed the density of D2 receptors was elevated in postmortem brains from schizophrenics. Genes which operate at the level of gene activation may be associated with the pathogenesis of schizophrenia. Arinami et al. [(1997) Human Molecular Genetics 6, 577-582] found a polymorphism in the 5'-flanking region of the D2 receptor gene designated as -141C Ins/Del. The promoter activity by luciferase assay of a plasmid containing the -141C Ins allele was higher than in the one… CONTINUE READING

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