Functional polymorphism in the alcohol dehydrogenase 3 (ADH3) promoter.

  title={Functional polymorphism in the alcohol dehydrogenase 3 (ADH3) promoter.},
  author={Jesper J Hedberg and Maria Backlund and Patrik Str{\"o}mberg and Sigrid L{\"o}nn and Marja Liisa Dahl and Magnus Ingelman-Sundberg and Jan Olov H{\"o}{\"o}g},
  volume={11 9},
The ADH3 gene encodes alcohol dehydrogenase 3 (ADH3)/glutathione-dependent formaldehyde dehydrogenase, the ancestral and most conserved form of alcohol dehydrogenase. ADH3 is expressed in all tissues examined and the enzyme is essential for formaldehyde scavenging. We have screened the promoter region including exon 1 and exons 5, 6 and 7 of the ADH3 gene for allelic variants. Using 80 samples of genomic DNA from Swedes as template, the various parts of the gene were PCR amplified and… CONTINUE READING
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