Functional plasticity of human respiratory tract dendritic cells: GM-CSF enhances T(H)2 development.

@article{Faith2005FunctionalPO,
  title={Functional plasticity of human respiratory tract dendritic cells: GM-CSF enhances T(H)2 development.},
  author={Alexander Faith and Joanne McDonald and Emma J Peek and David F. Richards and Jason Caulfield and Elfy B Chevretton and David J.S. Roberts and Tak Hong Lee and Christopher J. Corrigan and Catherine M Hawrylowicz},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={116 5},
  pages={1136-43}
}
BACKGROUND Dendritic cells within the human respiratory mucosa (RTDCs) are proposed to initiate immune responses to foreign antigens. Their capacity to polarize T-cell responses, however, has not been investigated. OBJECTIVE To compare RTDCs with peripheral blood dendritic cells (PBDCs) with regard to phenotype, cytokine production, capacity to polarize T-cell responses, and effects of exposure to the pleiotropic cytokine, GM-CSF. METHODS CD1a(+) RTDCs and CD1c(+) PBDCs were purified from… CONTINUE READING