Functional plasticity before the cradle: A review of neural functional imaging in the human fetus

  title={Functional plasticity before the cradle: A review of neural functional imaging in the human fetus},
  author={Amy L. Anderson and Moriah E. Thomason},
  journal={Neuroscience \& Biobehavioral Reviews},
Functional Connectivity of the Human Brain in Utero
Neonatal brain resting-state functional connectivity imaging modalities
Cognitive Functions of the Fetus.
Clinically relevant data on cognitive functions of the fetus could be important for the management of fetal pain and treatment of preterm infants as well as for improved neurodevelopmental outcome of fetuses from high-risk pregnancies.
The Brain before Birth: Using fMRI to Explore the Secrets of Fetal Neurodevelopment
  • Lindsey Konkel
  • Biology, Psychology
    Environmental health perspectives
  • 2018
Understanding the origins of neurodevelopment—and where brain function goes awry—may provide new insights on the impact of environmental exposures, and the findings could one day provide avenues for novel neuroprotective strategies.
Observing the origins of human brain development: Automated processing of fetal fMRI
This work presents the first open source, automated, start-to-finish processing pipeline for fetal fMRI data, and unifies the auto-masking model with a full processing pipeline and reports methodology, performance, and comparison to available alternatives.
Magnetoencephalography and the infant brain
Adaptive mechanisms of developing brain: Cerebral lateralization in the prematurely-born
Magnetic Source Imaging and Infant MEG: Current Trends and Technical Advances
The current review focuses on the source analysis of MEG measurement and its potential to answer critical questions on neural activation origins and patterns underlying infants’ early cognitive experience.
Automated Brain Masking of Fetal Functional MRI
This work solves the most challenging processing step, rapid and accurate isolation of the fetal brain from surrounding tissue across thousands of non-stationary 3D brain volumes, and unifies the auto-masking model with additional fMRI preprocessing steps from existing software and provides insight into each step.


Mapping fetal brain development in utero using magnetic resonance imaging: the Big Bang of brain mapping.
  • C. Studholme
  • Medicine
    Annual review of biomedical engineering
  • 2011
The developments that have led to this point are reviewed, the current state of the art in the fields of fast fetal imaging and motion correction are examined, and the tools to analyze dynamically changing fetal brain structure are described.
Cross-Hemispheric Functional Connectivity in the Human Fetal Brain
Resting-state functional magnetic resonance imaging is used to map the brain connections of 25 healthy singleton fetuses between 24 and 39 weeks of gestation and confirms the presence of bilateral functional connections in the fetal brain, as well as regional connections within each hemisphere.
Typical and Atypical Development of Functional Human Brain Networks: Insights from Resting-State fMRI
It is shown that rsfMRI studies help to clarify and reveal important principles of functional brain development, including a shift from diffuse to focal activation patterns, and simultaneous pruning of local connectivity and strengthening of long-range connectivity with age.
Normal Development of Brain Circuits
To contextualize the developmental origins of a wide array of neuropsychiatric illnesses, this review describes the development and maturation of neural circuits from the first synapse through critical periods of vulnerability and opportunity to the emergent capacity for cognitive and behavioral regulation, and finally the dynamic interplay across levels of circuit organization and developmental epochs.
Mapping the early cortical folding process in the preterm newborn brain.
This study investigates the sulcal emergence noninvasively in 35 preterm newborns, by applying dedicated postprocessing tools to magnetic resonance images acquired shortly after birth over a developmental period critical for the human cortex maturation (26-36 weeks of age).
Antenatal determination of fetal brain activity in response to an acoustic stimulus using functional magnetic resonance imaging
This study builds on earlier pilot work that showed that fMRI could provide direct evidence of fetal brain cortical activation in response to an auditory stimulus and aims to assess the sensitivity of this technique in a larger sample group.
Fetal brain activity in response to a visual stimulus
A fetal fMRI experiment using a visual stimulus has been performed at 0.5 T and activation was localised within the frontal cortex, which may correspond to the frontal eye fields and dorsolateral prefontal cortex.