Functional piglet model for the clinical syndrome and postmortem findings induced by staphylococcal enterotoxin B.

@article{Gessel2004FunctionalPM,
  title={Functional piglet model for the clinical syndrome and postmortem findings induced by staphylococcal enterotoxin B.},
  author={Yvonne A van Gessel and Sachin Mani and Shuguang Bi and Rasha Hammamieh and Jeffrey W. Shupp and Rina Das and Gary D. Coleman and Marty Jett},
  journal={Experimental biology and medicine},
  year={2004},
  volume={229 10},
  pages={1061-71}
}
Staphylococcal enterotoxin (SE) B causes serious gastrointestinal illness, and intoxication with this exotoxin can lead to lethal toxic shock syndrome. In order to overcome significant shortcomings of current rodent and nonhuman primate models, we developed a piglet model of lethal SEB intoxication. Fourteen-day-old Yorkshire piglets were given intravenous SEB, observed clinically, and sacrificed at 4, 6, 24, 48, 72, or 96 hrs posttreatment. Clinical signs were biphasic with pyrexia, vomiting… CONTINUE READING
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