Functional pathway mapping analysis for hypoxia-inducible factors

@inproceedings{Chuang2011FunctionalPM,
  title={Functional pathway mapping analysis for hypoxia-inducible factors},
  author={Chia-Sheng Chuang and Tun-Wen Pai and Chin-Hua Hu and Wen-Shyong Tzou and Margaret Dah-Tsyr Chang and Hao-Teng Chang and Chih-Chia Chen},
  booktitle={BMC Systems Biology},
  year={2011}
}
Hypoxia-inducible factors (HIFs) are transcription factors that play a crucial role in response to hypoxic stress in living organisms. The HIF pathway is activated by changes in cellular oxygen levels and has significant impacts on the regulation of gene expression patterns in cancer cells. Identifying functional conservation across species and discovering conserved regulatory motifs can facilitate the selection of reference species for empirical tests. This paper describes a cross-species… CONTINUE READING

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