Functional pathway-defined MRI diffusion measures reveal increased transverse diffusivity of water in multiple sclerosis

@article{Lowe2006FunctionalPM,
  title={Functional pathway-defined MRI diffusion measures reveal increased transverse diffusivity of water in multiple sclerosis},
  author={Mark J. Lowe and Craig Horenstein and Jochen G. Hirsch and Ruth Ann Marrie and Lael Stone and Pallab K. Bhattacharyya and Achim Gass and Micheal D. Phillips},
  journal={NeuroImage},
  year={2006},
  volume={32},
  pages={1127-1133}
}
The diffusion properties of water are sensitive to microscopic changes in the white matter of multiple sclerosis (MS) patients. Typical MRI measures of disease burden in MS demonstrate modest to poor correlation with disability. Functional MRI and DTI-based fiber tracking were used to define the interhemispheric white matter pathway connecting bilateral supplementary motor areas (SMA) in 16 MS patients sand 16 control subjects. Fractional anisotropy (FA), mean diffusivity (MD), longitudinal… CONTINUE READING

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