Functional overlaps between XLF and the ATM-dependent DNA double strand break response.

  title={Functional overlaps between XLF and the ATM-dependent DNA double strand break response.},
  author={Vipul Surender Kumar and Frederick W Alt and Valentyn Oksenych},
  journal={DNA repair},
Developing B and T lymphocytes generate programmed DNA double strand breaks (DSBs) during the V(D)J recombination process that assembles exons that encode the antigen-binding variable regions of antibodies. In addition, mature B lymphocytes generate programmed DSBs during the immunoglobulin heavy chain (IgH) class switch recombination (CSR) process that allows expression of different antibody heavy chain constant regions that provide different effector functions. During both V(D)J recombination… CONTINUE READING
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