Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9.

@article{Busconi2007FunctionalOO,
  title={Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9.},
  author={Liliana Busconi and Jason W. Bauer and Joseph R. Tumang and Amy M Laws and Kristin Perkins-Mesires and Abigail S. Tabor and Christina Lau and Ronald B. Corley and Thomas L. Rothstein and Frances E. Lund and Timothy W. Behrens and Ann Marshak-Rothstein},
  journal={Journal of immunology},
  year={2007},
  volume={179 11},
  pages={7397-405}
}
We have previously shown that rheumatoid factors produced by Fas-deficient autoimmune-prone mice typically bind autologous IgG2a with remarkably low affinity. Nevertheless, B cells representative of this rheumatoid factor population proliferate vigorously in response to IgG2a/chromatin immune complexes through a mechanism dependent on the sequential engagement of the BCR and TLR9. To more precisely address the role of both receptors in this response, we analyzed the signaling pathways activated… CONTINUE READING

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