Functional osteoclast-like transformation of cultured human myeloma cell lines.

  title={Functional osteoclast-like transformation of cultured human myeloma cell lines.},
  author={Nicola Calvani and Paola Cafforio and Francesco Silvestris and Franco Dammacco},
  journal={British journal of haematology},
  volume={130 6},
Hyperactive osteoclastogenesis is a hallmark of multiple myeloma, a B cell neoplasia homing to bone marrow and resulting in multiple osteolytic lesions and skeleton devastation. We provide evidence that myeloma cells can themselves act as osteoclasts in vitro. By extending standard cultures of U-266 and MCC-2 myeloma cell lines, we found that subsets of adherent cells also expressed the osteoclast phenotype, including multinuclear morphology, cytoplasmic tartrate-resistant acid phosphatase, the… CONTINUE READING
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