Functional organization of the retrotransposon Ty from Saccharomyces cerevisiae: Ty protease is required for transposition.

@article{Youngren1988FunctionalOO,
  title={Functional organization of the retrotransposon Ty from Saccharomyces cerevisiae: Ty protease is required for transposition.},
  author={S D Youngren and Jef D. Boeke and Norman Sanders and David J Garfinkel},
  journal={Molecular and cellular biology},
  year={1988},
  volume={8 4},
  pages={1421-31}
}
We used several mutations generated in vitro to further characterize the functions of the products encoded by the TyB gene of the transpositionally active retrotransposon TyH3 from Saccharomyces cerevisiae. Mutations close to a core protein domain of TyB, which is homologous to retroviral proteases, have striking effects on Ty protein processing, the physiology of Ty viruslike particles, and transposition. The Ty protease is required for processing of both TyA and TyB proteins. Mutations in the… CONTINUE READING

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