Functional organization of the main olfactory bulb

@article{Scott1993FunctionalOO,
  title={Functional organization of the main olfactory bulb},
  author={J. W. Scott and David P. Wellis and Marcia J. Riggott and Nathalie Buonviso},
  journal={Microscopy Research and Technique},
  year={1993},
  volume={24}
}
Complete understanding of the role of the mammalian main olfactory bulb in sensory processing has remained elusive despite many detailed studies on its anatomy and physiology. Several lines of recent evidence viewed in the context of earlier knowledge have provided new insights into the bulbar mechanisms of olfactory coding. The output cells of the olfactory bulb receive a localized olfactory nerve input and interneuronal input via dendrodendritic synapses on distinct sets of dendrites. The… Expand
Information processing in mammalian olfactory system.
TLDR
This review focuses on recent studies aimed at understanding the organizational strategies used by the mammalian olfactory system to encode information, and the onset of expression and the establishment of the zonal organization of odorant receptor genes in the epithelium are not dependent upon the presence of the Olfactory bulb. Expand
Synaptic Circuitry of Olfactory Bulb Glomeruli
The classic studies of Hirata [1], Pinching and Powell [2], White [3,4], and Hinds [5] established the fundamental synaptic organization of the mammalian olfactory bulb glomeruli. These studiesExpand
Subzonal organization of olfactory sensory neurons projecting to distinct glomeruli within the mouse olfactory bulb
TLDR
Transgenic mouse lines in which the projection of a neuron population expressing a particular receptor gene can be visualized as a result of axonal markers that are coexpressed are analyzed and the target glomeruli could thus reproducibly be identified and allowed to deposit retrograde tracers precisely. Expand
Olfactory processing in a changing brain.
TLDR
It is proposed that adult ongoing neurogenesis in the Olfactory bulb is associated with improved olfactory memory, and these recent findings not only provide new fuel for the molecular and cellular bases of sensory perception but should also shed light onto Cellular bases of learning and memory. Expand
Targeting of olfactory neurons
  • J. Strotmann
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • 2001
Abstract. Olfactory sensory neurons detect an enormous variety of small volatile molecules with extremely high sensitivity and specificity. The actual recognition and discrimination of odorousExpand
Investigation of the role of interneurons and their modulation by centrifugal fibers in a neural model of the olfactory bulb
TLDR
A neural model of the mammalian olfactory bulb is presented which allows to separately investigate the functional consequences of the two types of interneurons onto the relay neurons responsiveness to odors and proposes that the combined action of centrifugal control at two different layers of processing is complementary. Expand
Information processing in the mammalian olfactory system.
TLDR
Findings are presented that exemplified the high degree of olfactory plasticity, with special emphasis on the first central relay of the Olfactory system. Expand
Long-Term Plasticity in the Regulation of Olfactory Bulb Activity by Centrifugal Fibers from Piriform Cortex
TLDR
Functional plasticity in the AF pathway is explored by recording extracellularly from individual M/T cells and presumed granule cells in male Long–Evans rats under urethane anesthesia while testing their response to LOT and AF stimulation and document the long-lasting potentiation of that regulation by repeated high-frequency AF activation. Expand
A dendrodendritic reciprocal synapse provides a recurrent excitatory connection in the olfactory bulb
  • A. Didier, A. Carleton, +4 authors P. Lledo
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
TLDR
It is shown that MC excitation is caused by glutamate released from bulbar interneurons located in the GC layer, and this type of feedback excitation onto relay neurons may strengthen the original sensory input signal and further extend the function of the dendritic microcircuit within the main olfactory bulb. Expand
Target-independent pattern specification in the olfactory epithelium
TLDR
This work examined the onset of expression and patterning of genes encoding ORs and sensory transduction molecules during mouse embryogenesis and in mice lacking olfactory bulbs to argue for an independent development of epithelial and bulbar maps and an early functional development that may be pertinent to pattern development in the o aroma bulb. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 107 REFERENCES
Specific olfactory receptor populations projecting to identified glomeruli in the rat olfactory bulb.
TLDR
The data thus far demonstrate that functional units within the olfactory system may include not only glomeruli as previously suggested but, in addition, a corresponding matrix of receptor cells possessing functional and topographical specificity. Expand
Localized denervation demonstrates the innervation pattern of olfactory bulb glomeruli and second order cells
TLDR
Results show that primary olfactory axons and their terminals lie in parallel along the lateral face of the Olfactory bulb, maintained in the second order connections. Expand
Topographical relationships between olfactory receptor cells and glomerular foci in the rat olfactory bulb
TLDR
The findings demonstrate for the first time that the principal features of the regional organization of epithelium projections to a given bulbar surface are reproduced in any glomerular focus of this bul bar surface, and suggest that it could be the same for any single glomerulus. Expand
Response similarity to odors in olfactory bulb output cells presumed to be connected to the same glomerulus: electrophysiological study using simultaneous single-unit recordings.
TLDR
This work tested the hypothesis that the glomeruli, which appear to form anatomic units, could act to some extent as functional units and recorded the extracellular single-unit responses of pairs of M/T cells to a series of five odorants. Expand
Local information processing in dendritic trees: subsets of spines in granule cells of the mammalian olfactory bulb
TLDR
The data indicate that the functional organization of granule cell dendritic arbors is more complex than previously thought: between the level of the individual spine and the entire dendrite tree are several levels of subsets of spines that can mediate discrete localized inhibition onto subset of mitral or tufted cell secondary dendrites within the external plexiform layer of the olfactory bulb. Expand
Golgi analyses of dendritic organization among denervated olfactory bulb granule cells
  • C. Greer
  • Biology, Medicine
  • The Journal of comparative neurology
  • 1987
TLDR
The data are discussed in terms of subpopulations of granule cells in the mouse olfactory bulb, the sublaminar organization of olf factory bulb circuits, and the capacity for survival and plasticity in the reciprocal dendrodendritic circuits mediated by the granule cell spines. Expand
Evidence of lateral synaptic interactions in olfactory bulb output cell responses to odors
TLDR
It is demonstrated that lateral synaptic interactions within the olfactory bulb influence output cell responses to odor stimulation, as well as the inter-cell distance between these cells. Expand
The primary olfactory projection has two chemically distinct zones
  • J. Schwob, D. Gottlieb
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1986
TLDR
The sensory neurons of the olfactory epithelium form an anatomically uniform population but are differentially excited by odorants, and this heterogeneity is recognized by a newly generated monoclonal antibody, designated RB-8, that differentially stains the primary Olfactory projection in rats and divides it into 2 nonoverlapping zones. Expand
Pattern of rat olfactory bulb mitral and tufted cell connections to the anterior olfactory nucleus pars externa
TLDR
Reconstructions of axons showed that terminal branches arise from both mitral and tufted cells, although at least some mitral cells are shown not to have such branches in the pE AON. Expand
Atypical olfactory glomeruli contain original olfactory axon terminals: An ultrastructural horseradish peroxidase study in the rat
TLDR
Ulastructural features indicate that olfactory information processing taking place in the neuropil might be similar to that which occurs in typical glomeruli, which suggests that the atypical Olfactory neuroreceptors, glomersuli and acetylcholinesterase-containing centrifugal fibres could constitute a new olf factory subsystem. Expand
...
1
2
3
4
5
...