Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease

@article{Obeso2008FunctionalOO,
  title={Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease},
  author={J. Obeso and M. Rodriguez-Oroz and B. Ben{\'i}tez-Temi{\~n}o and Franscisco J. Blesa and J. Guridi and C. Mar{\'i}n and Manuel Rodriguez},
  journal={Movement Disorders},
  year={2008},
  volume={23}
}
The basal ganglia (BG) are a highly organized network, where different parts are activated for specific functions and circumstances. The BG are involved in movement control, as well as associative learning, planning, working memory, and emotion. We concentrate on the “motor circuit” because it is the best understood anatomically and physiologically, and because Parkinson's disease is mainly thought to be a movement disorder. Normal function of the BG requires fine tuning of neuronal… Expand

Paper Mentions

Observational Clinical Trial
Parkinson's disease is the second most common neurodegenerative disease affecting about 1-3% of population above 60 years. Recently, non-motor symptoms are getting more attention in PD… Expand
ConditionsParkinson's Disease
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References

SHOWING 1-10 OF 129 REFERENCES
The functions of the basal ganglia and the paradox of stereotaxic surgery in Parkinson's disease.
TLDR
It is concluded that the motor circuits of the basal ganglia are part of a distributed motor system which can operate, albeit imperfectly, in the absence of striato-pallido-thalamo-cortical feedback. Expand
Re-evaluation of the functional anatomy of the basal ganglia in normal and Parkinsonian states
TLDR
This article reviews recent data from different experimental approaches that challenge the established model of basal ganglia organization by reinterpreting the functional interaction between the external segment of the pallidum and the subthalamic nucleus in both the normal and pathological state. Expand
A new dynamic model of the cortico-basal ganglia loop.
  • A. Nambu
  • Biology, Medicine
  • Progress in brain research
  • 2004
TLDR
In this chapter, the functional significance of the 'hyperdirect' cortico-subthalamo-pallidal pathway is emphasized, and further a new dynamic model of basal ganglia function is presented. Expand
Dopamine Dependency of Oscillations between Subthalamic Nucleus and Pallidum in Parkinson's Disease
TLDR
Local potentials from the globus pallidus interna and subthalamic nucleus are recorded in four awake patients after neurosurgery for Parkinson's disease to demonstrate synchronization of activity does occur between pallidum and STN, and its pattern is critically dependent on the level of dopaminergic activity. Expand
The Basal Ganglia in Human Learning
  • C. Seger
  • Psychology, Medicine
  • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2006
TLDR
This review will focus on the roles of the basal ganglia in human learning, particularly sequence learning and category learning. Expand
The functional anatomy of basal ganglia disorders
TLDR
A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control. Expand
Multiple output channels in the basal ganglia.
TLDR
Retrograde transneuronal transport of herpes simplex virus type 1 was used to examine the organization of connections in the cebus monkey between an output nucleus of the basal ganglia, the internal segment of the globus pallidus, and three cortical areas: the primary motor cortex, the supplementary motor ara, and the ventral premotor area. Expand
The origin of motor fluctuations in Parkinson’s disease
TLDR
The severity of dopamine depletion and the consequent pathophysiologic changes that occur in basal ganglia circuits determine the severity of parkinsonian signs and treatments capable of providing and restoring more tonic and physiologic dopaminergic stimulation may avoid many of these abnormalities and lead to better clinical outcomes. Expand
Basal ganglia and cerebellar loops: motor and cognitive circuits
TLDR
Some of the new anatomical, physiological and behavioral findings that have contributed to a reappraisal of function concerning the basal ganglia and cerebellar loops with the cerebral cortex are reviewed. Expand
Metabolic effects of nigrostriatal denervation in basal ganglia
TLDR
In situ hybridization studies of cytochrome oxidase subunit I have confirmed the overactivity of the STN in the parkinsonian state and provided evidence that the change in STN activity is owing not only to decreased inhibition from the GPe but to hyperactivity of excitatory inputs from the parafascicular nucleus of the thalamus and the pedunculopontine nucleus in the brainstem. Expand
...
1
2
3
4
5
...