Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum

@article{Isacson1984FunctionalNR,
  title={Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum},
  author={O. Isacson and Patrik Brundin and Paul A. T. Kelly and Fred H. Gage and A. Bj{\"o}rklund},
  journal={Nature},
  year={1984},
  volume={311},
  pages={458-460}
}
In rats, striatal neuronal destruction by so-called excitotoxic amino acids, kainic acid or ibotenic acid (IA) produce neuropathological and neurochemical changes in the basal ganglia1–4 which resemble those seen in patients with Huntington's chorea5,6. Such lesioned animals show a behavioural syndrome which is reminiscent of the cardinal symptoms of the disease7–12, accompanied by a substantial increase in local cerebral metabolic activity in several striatal target structures within the… CONTINUE READING

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