Functional neuroimaging insights into how sleep and sleep deprivation affect memory and cognition

  title={Functional neuroimaging insights into how sleep and sleep deprivation affect memory and cognition},
  author={Michael W. L. Chee and Lisa Y. M. Chuah},
  journal={Current Opinion in Neurology},
Purpose of reviewThe review summarizes current knowledge about what fMRI has revealed regarding the neurobehavioral correlates of sleep deprivation and sleep-dependent memory consolidation. Recent findingsFunctional imaging studies of sleep deprivation have characterized its effects on a number of cognitive domains, the best studied of these being working memory. There is a growing appreciation that it is important to consider interindividual differences in vulnerability to sleep deprivation… 
Functional neuroimaging of sleep deprived healthy volunteers and persons with sleep disorders: a brief review.
This review highlights the recent functional neuroimaging studies on the brain's response while performing cognitive tasks when deprived of sleep and suggests reduced attention, accompanied by lowered parieto-occipital activation, may underlie performance decrements seen in other "higher cognitive domains".
About sleep's role in memory.
This review aims to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings.
The cognitive cost of sleep lost
Functional neuroimaging in sleep, sleep deprivation, and sleep disorders.
Flexibility of brain regions during working memory curtails cognitive consequences to lack of sleep
It is shown that the flexibility of particular brain regions that span a large network including regions in occipital, temporal, and frontal cortex increased when participants performed a working memory task following low sleep episodes, implying adaptability in brain networks to compensate for having a poor night's sleep.
Short-term memory deficits correlate with hippocampal-thalamic functional connectivity alterations following acute sleep restriction
It is indicated that the disruption of hippocampal–cortical connectivity is linked to the decline in short-term memory observed after acute sleep restriction, providing further evidence that support the cognitive impairment model of sleep deprivation.
Concurrent Impairments in Sleep and Memory in Amnestic Mild Cognitive Impairment
It is suggested that sleep changes in aMCI patients contribute to memory impairments by interfering with sleep-dependent memory consolidation.
Altered Functional Connectivity and Topological Organization of Brain Networks Correlate to Cognitive Impairments After Sleep Deprivation
The results suggested that the increased FC of DAN-SMN and decreased topological features of brain networks may act as neural indicators for the decrease in attention after SD.
Sleep Deprivation Promotes Habitual Control over Goal-Directed Control: Behavioral and Neuroimaging Evidence
It is suggested that people rely predominantly on habits at the expense of goal-directed control after sleep deprivation, and this process involves the ventromedial PFC, which provides novel evidence that goal- directed action may be particularly vulnerable to sleep loss.
The Effects of Sleep Deprivation on Item and Associative Recognition Memory
The results suggest that sleep deprivation degrades the quality of information stored in memory and that this may occur through degraded attentional processes.


Neurocognitive consequences of sleep deprivation.
Performance deficits associated with sleep disorders are often viewed as a simple function of disease severity; however, recent experiments suggest that individual vulnerability to sleep loss may play a more critical role than previously thought.
Altered brain response to verbal learning following sleep deprivation
It is shown that there are dynamic, compensatory changes in cerebral activation during verbal learning after sleep deprivation and the PFC and parietal lobes are implicated in this compensation.
Decreased brain activation during a working memory task at rested baseline is associated with vulnerability to sleep deprivation.
Preliminary data suggest that patterns of brain activation during the Sternberg working memory task at the rested baseline and the sleep- Deprivation state, differ across individuals as a function of their sleep-deprivation vulnerability.
A deficit in the ability to form new human memories without sleep
It appears that sleep before learning is critical in preparing the human brain for next-day memory formation—a worrying finding considering society's increasing erosion of sleep time.
Reproducibility of changes in behaviour and fMRI activation associated with sleep deprivation in a working memory task.
The reproducibility of fMRI activation and performance on a working memory task before and after 24 hours of sleep deprivation is assessed and the modulation of parietal activation may provide a good physiological marker of vulnerability to SD.
Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation
  • M. CheeY. M. Chuah
  • Psychology, Biology
    Proceedings of the National Academy of Sciences
  • 2007
A comparison between better and poorer performers showed that preservation of precuneus and temporoparietal junction deactivation with increasing memory load corresponds to less performance decline when one is sleep-deprived.