Functional neurogenesis in the adult hippocampus

  title={Functional neurogenesis in the adult hippocampus},
  author={Henriette van Praag and Alejandro F. Schinder and Brian R. Christie and Nicolas Toni and Theo D. Palmer and Fred H. Gage},
There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We… 

Generation of Functional Inhibitory Neurons in the Adult Rat Hippocampus

Using mutant Semliki Forest Virus vectors to express enhanced green fluorescent protein in the hippocampus, it is observed that ∼14% of newly generated neurons in the dentate gyrus of adult rats are GABAergic basket cells (BCs).

The dynamics of adult neurogenesis in human hippocampus

This paper explores the available data on as extent of adult hippocampal neurogenesis in humans and makes comparison to animal data.

Do new neurons have a functional role in the adult hippocampus?

Evidence to date strongly suggests that adult neurogenesis in the dentate gyrus plays a vital role in hippocampal function and killing or inhibiting proliferation of granule cell precursors impairs performance on several hippocampus-dependent tasks.

Neural Stem Cells in the Adult Hippocampus

The current understanding regarding neurogenesis in the adult dentate gyrus, the extent to which primitive neural progenitor cells in the hippocampus can be manipulated in vitro and in vivo, and the implications of hippocampal neuroGenesis for brain function and plasticity are summarized.

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain

It is suggested that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory.

Evidence for neurogenesis in the adult mammalian substantia nigra

  • Ming ZhaoS. Momma A. Janson
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2003
Evidence for the generation of dopaminergic projection neurons of the type that are lost in Parkinson's disease from stem cells in the adult rodent brain is provided and it is shown that the rate of neurogenesis is increased after a lesion.

Neurons born in the adult dentate gyrus form functional synapses with target cells

Structural and functional evidence indicates that axons of adult-born granule cells establish synapses with hilar interneurons, mossy cells and CA3 pyramidal cells and release glutamate as their main neurotransmitter.

Evidence for newly generated interneurons in the basolateral amygdala of adult mice

It is demonstrated that neurogenic precursor cells are present in the adult BLA, and generate functional interneurons, but also show that their activity is not regulated by an amygdala-dependent learning paradigm.

Neurogenesis in the Caudate Nucleus of the Adult Rabbit

The results suggest that neurogenesis in the caudate nucleus of rabbit is a phenomenon independent from that occurring in the adjacent subventricular zone, mostly attributable to the activity of clusters of proliferating cells located within the parenchyma of this nucleus.

Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus

It is proposed that neurons born in the developing and adult hippocampus constitute a functionally homogeneous neuronal population, and that adult-born neurons can fire action potentials in response to an excitatory drive.



Neurogenesis in the adult human hippocampus

It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.

Continuation of neurogenesis in the hippocampus of the adult macaque monkey.

  • D. R. KornackP. Rakic
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
This demonstration of adult neurogenesis in nonhuman Old World primates-with their phylogenetic proximity to humans, long life spans, and elaborate cognitive abilities-establishes the macaque as an unexcelled animal model to experimentally investigate issues of neurogen Genesis in humans and offers new insights into its significance in the adult brain.

Induction of neurogenesis in the neocortex of adult mice

It is shown that endogenous neural precursors can be induced in situ to differentiate into mature neurons, in regions of adult mammalian neocortex that do not normally undergo any neurogenesis.

More hippocampal neurons in adult mice living in an enriched environment

It is shown that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages, and that the enriched mice have a larger hippocampal granule cell layer and 15 per cent moregranule cell neurons in the Dentate Gyrus.

Vascular niche for adult hippocampal neurogenesis

The present data provide the first evidence that adult neurogenesis occurs within an angiogenic niche and may provide a novel interface where mesenchyme‐derived cells and circulating factors influence plasticity in the adult central nervous system.

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

It is confirmed that in the adult rat brain, neuronal progenitor cells divide at the border between the hilus and the granule cell layer (GCL) and in adult rats, the progeny of these cells migrate into the GCL and express the neuronal markers NeuN and calbindin-D28k.

Hippocampal stem cells differentiate into excitatory and inhibitory neurons

These data show that stem cells can be used to study mechanisms of excitation and inhibition in the nervous system and establish conditions that permit extensive maturation of neurons in the presence of neurotrophins.

In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus

The adult human hippocampus contains mitotically competent neuronal progenitors that can be selectively extracted, and the isolation of these cells may provide a cellular substrate for re-populating the damaged or degenerated adult hippocampus.

Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus

Observations indicate that prolonged seizure discharges stimulate dentate granule cell neurogenesis, and that hippocampal network plasticity associated with epileptogenesis may arise from aberrant connections formed by newly born dentategranule cells.