Functional network integration of embryonic stem cell-derived astrocytes in hippocampal slice cultures.

@article{Scheffler2003FunctionalNI,
  title={Functional network integration of embryonic stem cell-derived astrocytes in hippocampal slice cultures.},
  author={Bjoern Scheffler and Tanja Schmandt and Wolfgang Schroeder and Barbara Steinfarz and Leila Husseini and J{\"o}rg Wellmer and Gerald Seifert and Khalad Karram and Heinz Beck and I. Bluemcke and Otmar Dieter Wiestler and Christian Steinh{\"a}user and Oliver Bruestle},
  journal={Development},
  year={2003},
  volume={130 22},
  pages={5533-41}
}
Embryonic stem (ES) cells provide attractive prospects for neural transplantation. So far, grafting strategies in the CNS have focused mainly on neuronal replacement. Employing a slice culture model, we found that ES cell-derived glial precursors (ESGPs) possess a remarkable capacity to integrate into the host glial network. Following deposition on the surface of hippocampal slices, ESGPs actively migrate into the recipient tissue and establish extensive cell-cell contacts with recipient glia… CONTINUE READING

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