Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-beta-D-arabinofuranosylcytosine sensitivity may predict clinical response in acute myeloid leukemia.

@article{Schuurhuis1995FunctionalMR,
  title={Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-beta-D-arabinofuranosylcytosine sensitivity may predict clinical response in acute myeloid leukemia.},
  author={Gerrit J Schuurhuis and H J Broxterman and G J Ossenkoppele and J P Baak and C. A. Eekman and Catharina M. Kuiper and N Feller and T. H. van Heijningen and E Klumper and R Pieters},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1995},
  volume={1 1},
  pages={81-93}
}
  • Gerrit J Schuurhuis, H J Broxterman, +7 authors R Pieters
  • Published 1995 in
    Clinical cancer research : an official journal of…
Overexpression of P-glycoprotein (Pgp) or MDR1 mRNA has been shown to be a negative prognostic factor for clinical outcome in acute myeloid leukemia (AML). However, resistance to chemotherapy also occurs in the absence of Pgp overexpression. Therefore, besides Pgp expression, we have assessed the expression of MRP, a novel drug transporter gene, along with the functional multidrug-resistant (MDR) phenotype of leukemic cells. These MDR parameters are correlated with clinical outcome in… CONTINUE READING