Functional modules integrating essential cellular functions are predictive of the response of leukaemia cells to DNA damage

  title={Functional modules integrating essential cellular functions are predictive of the response of leukaemia cells to DNA damage},
  author={Katrin Sameith and Philipp Antczak and Elliott J Marston and Nil Turan and Dieter Maier and Tatjana Stankovic and Francesco Falciani},
  volume={24 22},
MOTIVATION Childhood B-precursor lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Despite the fact that 80% of ALL patients respond to anti-cancer drugs, the patho-physiology of this disease is still not fully understood. mRNA expression-profiling studies that have been performed have not yet provided novel insights into the mechanisms behind cellular response to DNA damage. More powerful data analysis techniques may be required for identifying novel functional pathways… 

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