Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts.

@article{Radicke2006FunctionalMO,
  title={Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts.},
  author={Susanne Radicke and Diego Cotella and Eva Maria Graf and Ulrich Banse and Norbert Jost and Andr{\'a}s Varr{\'o} and G. H. Tseng and Ursula Ravens and Erich Wettwer},
  journal={Cardiovascular research},
  year={2006},
  volume={71 4},
  pages={
          695-703
        }
}
OBJECTIVES The function of Kv4.3 (KCND3) channels, which underlie the transient outward current I(to) in human heart, can be modulated by several accessory subunits such as KChIP2 and KCNE1-KCNE5. Here we aimed to determine the regional expression of Kv4.3, KChIP2, and KCNE mRNAs in non-failing and failing human hearts and to investigate the functional consequences of subunit coexpression in heterologous expression systems. METHODS We quantified mRNA levels for two Kv4.3 isoforms, Kv4.3-S and… CONTINUE READING
Highly Cited
This paper has 99 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation.

Circulation. Arrhythmia and electrophysiology • 2011
View 4 Excerpts
Highly Influenced

Accessory subunits alter the temperature sensitivity of Kv4.3 channel complexes.

Journal of molecular and cellular cardiology • 2013
View 8 Excerpts
Method Support
Highly Influenced

100 Citations

051015'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 100 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 29 references

The MinK-related peptides

Neuropharmacology • 2004
View 2 Excerpts

A - type K + channels

SS Po, RC Wu, GJ Juang, W Kong, GF Tomaselli
2003