Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation.

  title={Functional modulation of GABAA receptors by cAMP-dependent protein phosphorylation.},
  author={Stephen J. Moss and Trevor G Smart and Craig D. Blackstone and Richard L. Huganir},
  volume={257 5070},
gamma-Aminobutyric acidA (GABAA) receptors are ligand-gated ion channels that mediate inhibitory synaptic transmission in the central nervous system. The role of protein phosphorylation in the modulation of GABAA receptor function was examined with cells transiently transfected with GABAA receptor subunits. GABAA receptors consisting of the alpha 1 and beta 1 or the alpha 1, beta 1, and gamma 2 subunits were directly phosphorylated on the beta 1 subunit by adenosine 3',5'-monophosphate (cAMP… CONTINUE READING
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