Functional modulation of ATPase of P-glycoprotein by C219, a monoclonal antibody against P-glycoprotein.

Abstract

P-glycoprotein functions as an ATP-driven efflux pump for antitumor agents. C219 is a monoclonal antibody which recognizes regions near both ATP binding domains in each half of P-glycoprotein. In this study, we have demonstrated that C219 inhibits the ATPase activity of P-glycoprotein based on the following findings: 1) the inhibition of total ATPase… (More)

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@article{Kokubu1997FunctionalMO, title={Functional modulation of ATPase of P-glycoprotein by C219, a monoclonal antibody against P-glycoprotein.}, author={N Kokubu and David E. Cohen and T Watanabe}, journal={Biochemical and biophysical research communications}, year={1997}, volume={230 2}, pages={398-401} }