Functional modularity of the beta-subunit of voltage-gated Ca2+ channels.

  title={Functional modularity of the beta-subunit of voltage-gated Ca2+ channels.},
  author={Lin-ling He and Yun Zhang and Yu-hang Chen and Yoichi Yamada and Jian Ming Yang},
  journal={Biophysical journal},
  volume={93 3},
The beta-subunit of voltage-gated Ca(2+) channels plays a dual role in chaperoning the channels to the plasma membrane and modulating their gating. It contains five distinct modular domains/regions, including the variable N- and C-terminus, a conserved Src homology 3 (SH3) domain, a conserved guanylate kinase (GK) domain, and a connecting variable and flexible HOOK region. Recent crystallographic studies revealed a highly conserved interaction between the GK domain and alpha interaction domain… CONTINUE READING

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