Functional mitochondria are required for alpha-synuclein toxicity in aging yeast.


alpha-Synuclein is one of the principal toxic triggers of Parkinson disease, an age-associated neurodegeneration. Using old yeast as a model of alpha-synuclein expression in post-mitotic cells, we show that alpha-synuclein toxicity depends on chronological aging and results in apoptosis as well as necrosis. Neither disruption of key components of the… (More)
DOI: 10.1074/jbc.M708477200