Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion.

@article{Caprio2008FunctionalMR,
  title={Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion.},
  author={Massimiliano Caprio and Brenna G. Newfell and Andrea la Sala and W. Baur and Andrea G. Fabbri and Giuseppe M. C. Rosano and Michael E. Mendelsohn and Iris Z Jaffe},
  journal={Circulation research},
  year={2008},
  volume={102 11},
  pages={1359-67}
}
In clinical trials, aldosterone antagonists decrease cardiovascular mortality and ischemia by unknown mechanisms. The steroid hormone aldosterone acts by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor. In humans, aldosterone causes MR-dependent endothelial cell (EC) dysfunction and in animal models, aldosterone increases vascular macrophage infiltration and atherosclerosis. MR antagonists inhibit these effects without changing blood pressure, suggesting… CONTINUE READING

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