Functional meaning of tryptophan-induced increase of 5-HT metabolism as clarified by in vivo voltammetry.

@article{Simoni1987FunctionalMO,
  title={Functional meaning of tryptophan-induced increase of 5-HT metabolism as clarified by in vivo voltammetry.},
  author={Maria-Grazia De Simoni and A Sokola and F Fodritto and G Dal Toso and Sergio Algeri},
  journal={Brain research},
  year={1987},
  volume={411 1},
  pages={89-94}
}
Differential pulse voltammetry with carbon fiber electrodes was used to study serotonin (5-HT) metabolism in freely moving rats. The electrodes implanted in the striatum recorded the extracellular 5-hydroxyindoleacetic acid (5-HIAA) oxidation peak after oral tryptophan (150 mg/kg). This 5-HT precursor did not modify the 5-HIAA peak in any rat tested, but it raised 5-HIAA levels determined in total tissue by a classical biochemical method (HPLC). The administration of 5-hydroxytryptophan (5-HTP… CONTINUE READING

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