Functional maternal catechol-O-methyltransferase polymorphism and fetal growth restriction.

OBJECTIVES The pathophysiologic processes that occur at the cellular and molecular levels in intrauterine fetal growth restriction are largely unknown. Catechol-O-methyltransferase (COMT) is a phase II enzyme that inactivates catechol estrogens by transfer of a methyl group. A functional Val158Met polymorphism in the COMT gene has been known as a… CONTINUE READING