Functional mapping of the GAGA factor assigns its transcriptional activity to the C-terminal glutamine-rich domain.

@article{Vaquero2000FunctionalMO,
  title={Functional mapping of the GAGA factor assigns its transcriptional activity to the C-terminal glutamine-rich domain.},
  author={Antonio Vaquero and Maria Lluisa Espinas and Fernando Azor{\'i}n and Jordi Bernu{\'e}s},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 26},
  pages={19461-8}
}
GAGA is a nuclear protein encoded by the Trithorax-like gene in Drosophila that is expressed in at least two isoforms generated by alternative splicing. By means of its specific interaction with DNA, GAGA has been involved in several nuclear transactions including regulation of gene expression. Here we have studied the GAGA(519) isoform as a transcription factor. In vitro, the transactivation domain has been assigned to the 93 C-terminal residues that correspond to a glutamine-rich domain (Q… CONTINUE READING

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Functional Mapping of the GAGA Factor 19468

  • F. Corpet
  • Nucleic Acids Res
  • 1988
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