Functional mapping — how to map and study the genetic architecture of dynamic complex traits

@article{Wu2006FunctionalM,
  title={Functional mapping — how to map and study the genetic architecture of dynamic complex traits},
  author={Rongling Wu and Min Lin},
  journal={Nature Reviews Genetics},
  year={2006},
  volume={7},
  pages={229-237}
}
  • R. WuMin Lin
  • Published 1 March 2006
  • Biology
  • Nature Reviews Genetics
The development of any organism is a complex dynamic process that is controlled by a network of genes as well as by environmental factors. Traditional mapping approaches for analysing phenotypic data measured at a single time point are too simple to reveal the genetic control of developmental processes. A general statistical mapping framework, called functional mapping, has been proposed to characterize, in a single step, the quantitative trait loci (QTLs) or nucleotides (QTNs) that underlie a… 
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320 Citations
Highly Influential Citations
4
Background Citations
141
Methods Citations
71
Results Citations
5

320 Citations

Functional Mapping: How to Map Genes for Phenotypic Plasticity of Development

The new framework for functional mapping enables geneticists to illustrate the genetic architecture of how QTLs cope with environment to regulate the developmental pattern and timing of phenotypic formation.

Functional mapping of developmental processes: theory, applications, and prospects.

The basic theory of functional mapping is reviewed and several areas in which functional mapping can be integrated with systems biology to further the understanding of the genetic and genetic regulatory underpinnings of development are pinpointed.

Functional Mapping of Multiple Dynamic Traits

A multivariate model for functional mapping that can detect and characterize quantitative trait loci (QTLs) that simultaneously control multiple dynamic traits that can aid in the comprehension of the genetic control mechanisms of complex dynamic traits over time is developed.

Functional Mapping of Multiple Dynamic Traits

A multivariate model for functional mapping that can detect and characterize quantitative trait loci (QTLs) that simultaneously control multiple dynamic traits that can aid in the comprehension of the genetic control mechanisms of complex dynamic traits over time is developed.

Systems mapping: how to improve the genetic mapping of complex traits through design principles of biological systems

Systems mapping implemented by design principles of biological systems is quite versatile for deciphering the genetic machineries for size-shape, structural-functional, sink-source and pleiotropic relationships underlying plant physiology and development.

Structural mapping: how to study the genetic architecture of a phenotypic trait through its formation mechanism

This work describes and assess a strategy to dissect the trait phenotype into its structural components and map specific QTLs that control the mechanistic and structural formation of a complex trait, by integrating the internal structural basis of trait formation into a QTL mapping framework.

Mapping genes for plant structure, development and evolution: functional mapping meets ontology.

Mapping complex traits as a dynamic system.

A dynamic model for functional mapping of biological rhythms

A new functional mapping framework for a dynamic biological rhythm is formulated by incorporating a group of ordinary differential equations (ODE) by incorporating the Runge–Kutta fourth-order algorithm to estimate the parameters that define the system of ODE.

A nonparametric approach for functional mapping of complex traits

This work addresses the issue to expand the applying scope of functional mapping by utilizing a nonparametric adaptive high-dimensional ANOVA (HANOVA) method and has successfully identified many signi ficant QTLs that control leaf shape.
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