Functional mapping — how to map and study the genetic architecture of dynamic complex traits
@article{Wu2006FunctionalM, title={Functional mapping — how to map and study the genetic architecture of dynamic complex traits}, author={R. Wu and M. Lin}, journal={Nature Reviews Genetics}, year={2006}, volume={7}, pages={229-237} }
The development of any organism is a complex dynamic process that is controlled by a network of genes as well as by environmental factors. Traditional mapping approaches for analysing phenotypic data measured at a single time point are too simple to reveal the genetic control of developmental processes. A general statistical mapping framework, called functional mapping, has been proposed to characterize, in a single step, the quantitative trait loci (QTLs) or nucleotides (QTNs) that underlie a… CONTINUE READING
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