Functional mapping — how to map and study the genetic architecture of dynamic complex traits

@article{Wu2006FunctionalM,
  title={Functional mapping — how to map and study the genetic architecture of dynamic complex traits},
  author={Rongling Wu and Min Lin},
  journal={Nature Reviews Genetics},
  year={2006},
  volume={7},
  pages={229-237}
}
  • R. Wu, Min Lin
  • Published 1 March 2006
  • Biology
  • Nature Reviews Genetics
The development of any organism is a complex dynamic process that is controlled by a network of genes as well as by environmental factors. Traditional mapping approaches for analysing phenotypic data measured at a single time point are too simple to reveal the genetic control of developmental processes. A general statistical mapping framework, called functional mapping, has been proposed to characterize, in a single step, the quantitative trait loci (QTLs) or nucleotides (QTNs) that underlie a… 
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306 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
60
Results Citations
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306 Citations

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Citation Type

Functional Mapping: How to Map Genes for Phenotypic Plasticity of Development
TLDR
The new framework for functional mapping enables geneticists to illustrate the genetic architecture of how QTLs cope with environment to regulate the developmental pattern and timing of phenotypic formation.
Functional mapping of developmental processes: theory, applications, and prospects.
TLDR
The basic theory of functional mapping is reviewed and several areas in which functional mapping can be integrated with systems biology to further the understanding of the genetic and genetic regulatory underpinnings of development are pinpointed.
Functional Mapping of Multiple Dynamic Traits
TLDR
A multivariate model for functional mapping that can detect and characterize quantitative trait loci (QTLs) that simultaneously control multiple dynamic traits that can aid in the comprehension of the genetic control mechanisms of complex dynamic traits over time is developed.
Structural mapping: how to study the genetic architecture of a phenotypic trait through its formation mechanism
TLDR
This work describes and assess a strategy to dissect the trait phenotype into its structural components and map specific QTLs that control the mechanistic and structural formation of a complex trait, by integrating the internal structural basis of trait formation into a QTL mapping framework.
Systems mapping: how to improve the genetic mapping of complex traits through design principles of biological systems
TLDR
Systems mapping implemented by design principles of biological systems is quite versatile for deciphering the genetic machineries for size-shape, structural-functional, sink-source and pleiotropic relationships underlying plant physiology and development.
A dynamic framework for quantifying the genetic architecture of phenotypic plasticity
TLDR
A dynamic model to map specific quantitative trait loci (QTLs) that affect the gradient expression of a quantitative trait across a range of environments is described and demonstrated by reanalyzing a QTL data set for rice, gleaning new insights into the genetic basis for phenotypic plasticity in plant height growth.
Mapping genes for plant structure, development and evolution: functional mapping meets ontology.
Mapping complex traits as a dynamic system.
A dynamic model for functional mapping of biological rhythms
TLDR
A new functional mapping framework for a dynamic biological rhythm is formulated by incorporating a group of ordinary differential equations (ODE) by incorporating the Runge–Kutta fourth-order algorithm to estimate the parameters that define the system of ODE.
A QTL model to map the common genetic basis for correlative phenotypic plasticity
TLDR
A statistical model for mapping specific quantitative trait loci that control the interrelationship of phenotypic plasticity between different traits that was validated through computer simulation and used to analyse multi-environment data of genetic mapping in winter wheat, showing its utilization in practice.
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