Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor.

@article{Gherardi2003FunctionalMA,
  title={Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor.},
  author={Ermanno Gherardi and Mark E Youles and Ricardo N{\'u}{\~n}ez Miguel and Tom L. Blundell and Luisa Iamele and Julian Gough and Abhishek Bandyopadhyay and Guido R. Hartmann and P. Jonathan G. Butler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 21},
  pages={12039-44}
}
Little is known about the large ectodomain of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor (HGF/SF). Here, we establish by deletion mutagenesis that the HGF/SF and heparin-binding sites of MET are contained within a large N-terminal domain spanning the alpha-chain (amino acids 25-307) and the first 212 amino acids of the beta-chain (amino acids 308-519). Neither the cystine-rich domain (amino acids 520-561) nor the C-terminal half of MET… CONTINUE READING
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