Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism

  title={Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism},
  author={Chris C. Streeter and Domenic A. Ciraulo and Gordon J. Harris and Marc J. Kaufman and R. F. Lewis and Clifford M. Knapp and Ann Marie Ciraulo and Luis C. Maas and Michelle Ungeheuer and Susan Szulewski and Perry F. Renshaw},
  journal={Psychiatry Research: Neuroimaging},

Altered benzodiazepine receptor sensitivity in alcoholism: A study with fMRI and acute lorazepam challenge

Increased sensitivity to alprazolam in females with a paternal history of alcoholism

Results suggest that FHP females may be more sensitive to the performance-impairing effects and negative subjective effects of alprazolam.

Decreased EEG Sensitivity to Alprazolam in Subjects with a Parental History of Alcoholism

The results suggest that PHP subjects are less sensitive to the effects of alprazolam on central electrophysiological activity than are NC subjects.

Impact of family history of alcoholism on cocaine-induced subjective effects and pharmacokinetic profile

The findings indicate that family history of alcoholism does not appear to influence the behavioral and physiological responses to acute cocaine administration, but that some aspects of cocaine metabolism may be different between the two groups.

Regional brain metabolism during alcohol intoxication.

The results support similar though not identical mechanisms for the effects of alcohol and benzodiazepines on brain glucose metabolism, and the fact that lorazepam, but not alcohol, reduced thalamic metabolism, an effect associated with sleepiness, could explain the higher sedative effects of lorzepam than of alcohol.

Neuropsychiatric dynamics: the study of mental illness using functional magnetic resonance imaging.

Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge

GABAergic modulation with alprazolam produced differential responses in family members vs. controls, perhaps by unmasking underlying amygdalar and/or GABAergic abnormalities, which could prove useful for developing drugs targeting specific neural circuits to treat or prevent schizophrenia.

Perfusion Magnetic Resonance Imaging in Psychiatry

  • J. Théberge
  • Medicine, Psychology
    Topics in magnetic resonance imaging : TMRI
  • 2008
This article aims to review the existing literature on applications of perfusion MRI in psychiatric disorder and substance abuse research and provides a brief introductory overview of dynamic susceptibility contrast MRI and arterial spin labeling techniques.

Magnetic Resonance Findings in Substance Abuse

To date, magnetic resonance (MR) technologies have been used primarily for clinical evaluation of patients with substance abuse-related neurologic complications, but experimental studies using MR to monitor the effects of drugs and alcohol on brain physiology and neurochemistry are increasingly being used.



Regional brain metabolic response to lorazepam in subjects at risk for alcoholism.

The decreased Cerebellar baseline metabolism in FP as well as the blunted cerebellar response to lorazepam challenge may reflect disrupted activity of benzodiazepine-GABA receptors in cerebellum, which could account for the decreased sensitivity to the motor effects of alcohol and benzodiazines in FP subjects.

Effects of diazepam on cerebral metabolism and mood in normal volunteers.

Diazepam decreased whole brain metabolic rate at doses that produced only modest subjective or behavioral effects, and the changes in metabolic rate were not clearly related to other observable drug effects.

Decreased cerebral response to inhibitory neurotransmission in alcoholics.

The alcoholic subjects had a blunted response to lorazepam that was specific to certain brain regions that was seen in the alcoholic subjects, suggesting that the cerebellum may contribute to the decreased sensitivity to lOrazepham.

The Effect of Diazepam Sedation on Cerebral Glucose Metabolism in Alzheimer's Disease as Measured Using Positron Emission Tomography

Utilization of diazepam sedation for PET study appears to be safe and may permit the study of patients otherwise unable to cooperate with FDG-PET procedures.

Liability to alprazolam abuse in daughters of alcoholics.

The findings of this study suggest that the mood-enhancing effects of alprazolam are greater in daughters of alcoholics than in subjects without a history of parental alcohol dependence.

Effects of Acute and Chronic Alprazolam Treatment on Cerebral Blood Flow, Memory, Sedation, and Plasma Catecholamines

There were no consistent regional neuroanatomic differences in the CBF effects of acuteAlprazolam, or in the development of tolerance to these effects, and no correlations between the various measures of acute alprazoam efects on either test day.

Visual laterality patterns for the perception of emotional words in alcoholic and aging individuals.

The findings support the suggestion that alcoholics may have deficient right-hemisphere functioning, and the idea of synergism between alcoholism and aging with respect to perceptual asymmetries was not supported.

Functional MR in the evaluation of dementia: correlation of abnormal dynamic cerebral blood volume measurements with changes in cerebral metabolism on positron emission tomography with fludeoxyglucose F 18.

Cerebral blood volumes images derived from magnetic susceptibility (functional MR) provide information similar to fludeoxyglucose F 18 PET images in demented patients undergoing evaluation for dementia.