Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism

@article{Streeter1998FunctionalMR,
  title={Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism},
  author={Chris C. Streeter and Domenic A. Ciraulo and Gordon J. Harris and Marc J. Kaufman and R. F. Lewis and Clifford M. Knapp and Ann Marie Ciraulo and Luis C. Maas and Michelle Ungeheuer and Susan Szulewski and Perry F. Renshaw},
  journal={Psychiatry Research: Neuroimaging},
  year={1998},
  volume={82},
  pages={69-82}
}

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Increased sensitivity to alprazolam in females with a paternal history of alcoholism

TLDR
Results suggest that FHP females may be more sensitive to the performance-impairing effects and negative subjective effects of alprazolam.

Decreased EEG Sensitivity to Alprazolam in Subjects with a Parental History of Alcoholism

TLDR
The results suggest that PHP subjects are less sensitive to the effects of alprazolam on central electrophysiological activity than are NC subjects.

Impact of family history of alcoholism on cocaine-induced subjective effects and pharmacokinetic profile

TLDR
The findings indicate that family history of alcoholism does not appear to influence the behavioral and physiological responses to acute cocaine administration, but that some aspects of cocaine metabolism may be different between the two groups.

Regional brain metabolism during alcohol intoxication.

TLDR
The results support similar though not identical mechanisms for the effects of alcohol and benzodiazepines on brain glucose metabolism, and the fact that lorazepam, but not alcohol, reduced thalamic metabolism, an effect associated with sleepiness, could explain the higher sedative effects of lorzepam than of alcohol.

Neuropsychiatric dynamics: the study of mental illness using functional magnetic resonance imaging.

Amygdala abnormalities in first-degree relatives of individuals with schizophrenia unmasked by benzodiazepine challenge

TLDR
GABAergic modulation with alprazolam produced differential responses in family members vs. controls, perhaps by unmasking underlying amygdalar and/or GABAergic abnormalities, which could prove useful for developing drugs targeting specific neural circuits to treat or prevent schizophrenia.

Perfusion Magnetic Resonance Imaging in Psychiatry

  • J. Théberge
  • Medicine, Psychology
    Topics in magnetic resonance imaging : TMRI
  • 2008
TLDR
This article aims to review the existing literature on applications of perfusion MRI in psychiatric disorder and substance abuse research and provides a brief introductory overview of dynamic susceptibility contrast MRI and arterial spin labeling techniques.

Magnetic Resonance Findings in Substance Abuse

TLDR
To date, magnetic resonance (MR) technologies have been used primarily for clinical evaluation of patients with substance abuse-related neurologic complications, but experimental studies using MR to monitor the effects of drugs and alcohol on brain physiology and neurochemistry are increasingly being used.

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TLDR
The decreased Cerebellar baseline metabolism in FP as well as the blunted cerebellar response to lorazepam challenge may reflect disrupted activity of benzodiazepine-GABA receptors in cerebellum, which could account for the decreased sensitivity to the motor effects of alcohol and benzodiazines in FP subjects.

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TLDR
The alcoholic subjects had a blunted response to lorazepam that was specific to certain brain regions that was seen in the alcoholic subjects, suggesting that the cerebellum may contribute to the decreased sensitivity to lOrazepham.

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TLDR
The findings of this study suggest that the mood-enhancing effects of alprazolam are greater in daughters of alcoholics than in subjects without a history of parental alcohol dependence.

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TLDR
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TLDR
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TLDR
Cerebral blood volumes images derived from magnetic susceptibility (functional MR) provide information similar to fludeoxyglucose F 18 PET images in demented patients undergoing evaluation for dementia.