Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteers.

@article{Becerra2006FunctionalMR,
  title={Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteers.},
  author={Lino Becerra and Kim Harter and R Gilberto Gonz{\'a}lez and David Borsook},
  journal={Anesthesia and analgesia},
  year={2006},
  volume={103 1},
  pages={208-16, table of contents}
}
In this pilot study, we used functional magnetic resonance imaging (fMRI) to study the effects of morphine in 8 healthy, opioid-naïve volunteers. Intravenous small-dose morphine (4 mg/70 kg) or saline was administered to volunteers undergoing a fMRI scan. Infusion of morphine, but not saline, elicited mild euphoria without aversive symptoms and resulted in positive signal changes in reward structures including the nucleus accumbens, sublenticular extended amygdala, orbitofrontal cortex, and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 53 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Opioid Analgesics and Antagonists

  • JH Jaffe, WR Martin
  • 1990
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…