Functional localization and competition between the androgen receptor and T-cell factor for nuclear β-catenin: a means for inhibition of the Tcf signaling axis

@article{Mulholland2003FunctionalLA,
  title={Functional localization and competition between the androgen receptor and T-cell factor for nuclear β-catenin: a means for inhibition of the Tcf signaling axis},
  author={David J. Mulholland and Jason Tyler Read and Paul S. Rennie and Michael E. Cox and Colleen C. Nelson},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={5602-5613}
}
Recent reports suggest that the β-catenin-T-cell factor (Tcf) (BCT) signaling pathway is important in the progression of prostate cancer. Evidence suggests that the androgen receptor (AR) can repress BCT-mediated transcription both in prostate cancer and colon cancer cells (Chesire and Isaacs, 2002). In this study, we validate such findings and show that repression of BCT signaling is facilitated by competition between the AR and Tcf. Measurements of the Tcf transcriptional reporter (TOPFLASH… CONTINUE READING
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