Functional links between Snail-1 and Cx43 account for the recruitment of Cx43-positive cells into the invasive front of prostate cancer.

@article{Ryszawy2014FunctionalLB,
  title={Functional links between Snail-1 and Cx43 account for the recruitment of Cx43-positive cells into the invasive front of prostate cancer.},
  author={Damian Ryszawy and Michał Sarna and Monika Rak and Katarzyna Szpak and Sylwia Kędracka-Krok and Marta Michalik and Maciej Siedlar and Ewa K. Zuba-Surma and Květoslava Burda and Włodzimierz Korohoda and Zbigniew Madeja and Jaroslaw A Czyz},
  journal={Carcinogenesis},
  year={2014},
  volume={35 9},
  pages={1920-30}
}
Suppressive function of connexin(Cx)43 in carcinogenesis was recently contested by reports that showed a multifaceted function of Cx43 in cancer progression. These studies did not attempt to model the dynamics of intratumoral heterogeneity involved in the metastatic cascade. An unorthodox look at the phenotypic heterogeneity of prostate cancer cells in vitro enabled us to identify links between Cx43 functions and Snail-1-regulated functional speciation of invasive cells. Incomplete Snail-1… CONTINUE READING

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