Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.

@article{Hadano2016FunctionalLB,
  title={Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.},
  author={Shinji Hadano and Shun Mitsui and Lei Pan and Asako Otomo and Mizuki Kubo and K Sato and Suzuka Ono and Wakana Onodera and Koichiro Abe and Yongping Chen and Masato Koike and Yasuo Uchiyama and Masashi Aoki and Eiji Warabi and Masayuki Yamamoto and Tsuyoshi Ishii and Toru Yanagawa and Huifang Shang and Fumihito Yoshii},
  journal={Human molecular genetics},
  year={2016},
  volume={25 15},
  pages={
          3321-3340
        }
}
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by a selective loss of motor neurons in the brain and spinal cord. Multiple toxicity pathways, such as oxidative stress, misfolded protein accumulation, and dysfunctional autophagy, are implicated in the pathogenesis of ALS. However, the molecular basis of the interplay between such multiple factors in vivo remains unclear. Here, we report that two independent ALS-linked autophagy-associated gene products… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 90 REFERENCES

Amyotrophic lateral sclerosis models and human neuropathology: similarities and differences

  • S. Kato
  • Acta Neuropathol.,
  • 2008
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…