Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton

  title={Functional linkage of the cardiac ATP-sensitive K+ channel to the actin cytoskeleton},
  author={Tetsushi Furukawa and Tei-ichi Yamane and Tomoko Terai and Yoshifumi Katayama and Masayasu Hiraoka},
  journal={Pfl{\"u}gers Archiv},
The role of the cytoskeleton in the rundown and reactivation of adenosine triphosphate (ATP) sensitive K+ channels (KATP channels) was examined by perturbing selectively the intracellular surface of inside-out membrane patches excised from guinea-pig ventricular myocytes. Actin filament-depolymerizing agents (cytochalasins and desoxyribonuclease I) accelerated channel rundown, while actin filament stabilizer (phalloidin) or phosphatidylinositol biphosphate (PIP2; inhibitor of F-actin-severing… CONTINUE READING
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Actin microfilament-disrupters antagonize ATP-dependent gating of cardiac ATP-sensitive K+ channels (abstract)

  • A Terzic, Y Kurachi
  • Biophys J 68:A41
  • 1995
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